2017

MARTINELLI, L. K.; ROTTA, M.; VILLELA, A. D.; RODRIGUES-JUNIOR, V. S.; ABBADI, B. L.; TRINDADE, R. V.; PETERSEN, G. O.; DANESI, G.; NERY, L.; PAULI, I.; CAMPOS, M. M.; BONAN, C. D.; SOUZA, O. N.; BASSO, L. A.; SANTOS, D. S. Functional, thermodynamics, structural and biological studies of in silico-identified inhibitors of Mycobacterium tuberculosis enoyl-ACP(CoA) reductase enzyme. Scientific Reports, epub ahead of print, 2017.

GAZZI, T.; ROTTA, M.; VILLELA, A.; RODRIGUES-JUNIOR, V.; MARTINELLI, L.; SALES, F.; DE SOUSA, E.; CAMPOS, M.; BASSO, L.; SANTOS, D.; MACHADO, P. Synthesis, Inhibition of Mycobacterium tuberculosis Enoyl-acyl Carrier Protein Reductase and Antimycobacterial Activity of Novel Pentacyanoferrate(II)-isonicotinoylhydrazones. Journal of the Brazilian Chemical Society, epub ahead of print, 2017.

FALCÃO, V. C.; VILLELA, A. D.; RODRIGUES-JUNIOR, V. S.; PISSINATE, K.; EICHLER, P.; PINTO, A. F.; BASSO, L. A.; SANTOS, D. S.; BIZARRO, C. V. Validation of Mycobacterium tuberculosis dihydroneopterin aldolase as a molecular target for anti-tuberculosis drug development. Biochemical Biophysical Research Communications, v. 485, p. 814-819, 2017.

RODRIGUES-JUNIOR, V. S.; MACHADO, P.; CALIXTO, J. B.; SIQUEIRA, J. M.; ANDRADE, E.; BENTO, A.; CAMPOS, M. M.; BASSO, L. A.; SANTOS, D. S. Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies. Regulatory Toxicology and Pharmacology, v. 86, p. 11-17, 2017.

VILLELA, A. D.; RODRIGUES-JUNIOR, V. S.; PINTO, A. F.; WINK, P. L.; SÁNCHEZ-QUITIAN, Z. A.; PETERSEN, G. O.; CAMPOS, M. M.; BASSO, L. A.; SANTOS, D. S. Characterisation of iunH gene knockout strain from Mycobacterium tuberculosis. Memórias do Instituto Oswaldo Cruz, v. 112, p. 203-208, 2017.

VILLELA, A. D.; PHAM, H.; JONES, V.; GRZEGORZEWICZ, A. E.; RODRIGUES-JUNIOR, V. S.; CAMPOS, M. M.; BASSO, L. A.; JACKSON, M.; SANTOS, D. S. Analysis of uracil phosphoribosyltransferase expression in Mycobacterium tuberculosis and evaluation of upp knockout strain in infected mice. FEMS Microbiology Letters, v. 364, fnx023, 2017.

GIACOBBO, B. C.; PISSINATE, K.; RODRIGUES-JUNIOR, V.; VILLELA, A. D.; GRAMS, E. S.; ABBADI, B. L.; SUBTIL, F. T.; SPEROTTO, N.; TRINDADE, R. V.; BACK, D. F.; CAMPOS, M. M.; BASSO, L. A.; MACHADO, P.; SANTOS, D. S. New insights into the SAR and drug combination synergy of 2-(quinolin-4-yloxy)acetamides against Mycobacterium tuberculosis. European Journal of Medicinal Chemistry, v. 126, p. 491-501, 2017.

2016

RODRIGUES-JUNIOR, V. S.; VILLELA, A. D.; GONÇALVES, R. S. B.; ABBADI, B. L.; TRINDADE, R. V.; LÓPEZ-GAVÍN, A.; GONZÁLEZ-MARTÍN, J.; BASSO, LA; SOUZA, M. V. N.; CAMPOS, M. M.; SANTOS, D. S. Mefloquine and its oxazolidine derivative compound are active against drug-resistant Mycobacterium tuberculosis strains and in a murine model of tuberculosis infection. International Journal of Antimicrobial Agents, v. 48, p. 203-207, 2016.

LUNARDI, J.; MARTINELLI, L. K. B.; RAUPP, A. S.; NUNES, J. E. S.; ROSTIROLLA, D. C.; TIMMERS, L. F. S. M.; VILLELA, A. D.; PISSINATE, K.; LIMBERGER, J.; SOUZA, O. N.; BASSO, L. A.; SANTOS, D. S.; MACHADO, P. Mycobacterium tuberculosis histidinol dehydrogenase: biochemical characterization and inhibition studies. RSC Advances, v. 6, p. 28406-28418, 2016.

PISSINATE, K.; VILLELA, A. D.; RODRIGUES-JUNIOR, V.; GIACOBBO, B. C.; GRAMS, E. S.; ABBADI, B. L.; TRINDADE, R. V.; ROESLER, N. L.; BONAN, C. D.; BACK, D. F.; CAMPOS, M. M.; BASSO, L. A.; SANTOS, D. S.; MACHADO, P. 2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains. ACS Medicinal Chemistry Letters, v. 7, p. 235-239, 2016.

TRINDADE, R. V.; PINTO, A. F.; SANTOS, D. S.; BIZARRO, C. V. Pulse Proteolysis and Precipitation for Target Identification. Journal of Proteome Research, v. 15, p. 2236-2245, 2016.

CATTANEO, G.; UBIALI, D.; CALLERI, E.; RABUFFETTI, M.; HÖFNER, G. C.; WANNER, K. T.; DE MORAES, M. C.; MARTINELLI, L. K.; SANTOS, D. S.; SPERANZA, G.; MASSOLINI, G. Development, validation and application of a 96-well enzymatic assay based on LC-ESI-MS/MS quantification for the screening of selective inhibitors against Mycobacterium tuberculosis purine nucleoside phosphorylase. Analytica Chimica Acta, v. 943, p. 89-97, 2016.

DADDA, A. S.; RODRIGUES JUNIOR, V.; ROTTA, M.; MARTINELLI, L. K.; CAMPOS, M. M.; SOUSA, E. H. S.; PINTO, A. F. M.; MACHADO, P.; BASSO, L. A.; SANTOS, D. S . Voltametric detection and quantification of pentacyano(isoniazid)ferrateII, a metal-based drug candidate for the treatment of tuberculosis. Current Topics in Pharmacology, v. 19, p. 75-86, 2016.

KRITSKI, A.; BARREIRA, D.; JUNQUEIRA-KIPNIS, A. P.; MORAES, M. O.; CAMPOS, M. M.; DEGRAVE, W. M.; MIRANDA, S. S.; KRIEGER, M. A.; CHIMARA, E.; MOREL, C.; DALCOLMO, M. P.; MACIEL, E. L. N.; EVANGELISTA, M. S. N.; VILLA, T. S.; SANCHEZ, M.; COSTA, F. D.; QUEIROZ, I.; OLIVEIRA, M. M.; SOUZA JUNIOR, R.; SILVA, J. R. L.; RUFFINO-NETTO, A. Brazilian Response to Global End TB Strategy : The National Tuberculosis Research Agenda. Sociedade Brasileira de Medicina Tropical. Revista, v. 49, p. 135-145, 2016.

KRITSKI, A. L.; RUFFINO-NETTO, A.; TRAJMAN, A.; VILLA, T. C. S.; SILVA, J. R. L.; HADAD, D.; MACIEL, E. L. N.; NETO, E.; SANTANA, C. C.; GOBARDO, B. M. A.; ROSSONI, A. M. O.; BASTA, P. C.; ANDRADE, M. K.; SILVA, C. L.; SANTOS, D. S.; OLIVEIRA, M. M.; SILVA, P. E. A. Rede brasileira de pesquisa em tuberculose- REDE TB. Instituto de Higiene e Medicina Tropical, v. 15, p. 535-544, 2016.

WYSOCKI, A. D.; VILLA, T. C. S.; ARAKAWA, T.; BRUNELLO, M. E. F.; VENDRAMINI, S. H. F.; MONROE, A. A.; KRITSKI, A. L. Latent Tuberculosis Infection Diagnostic and Treatment Cascade among Contacts in Primary Health Care in a City of Sao Paulo State, Brazil: Cross-Sectional Study. Plos One, v. 11, p. e0155348, 2016.

DE O. SOUZA FILHO, J. B.; DE SEIXAS, J. M.; GALLIEZ, R.; DE BRAGANÇA PEREIRA, B.; DE Q MELLO, F. C.; DOS SANTOS, A. M.; KRITSKI, A. L. A screening system for smear-negative pulmonary tuberculosis using artificial neural networks. International Journal of Infectious Diseases, v. 24, p. 33-39, 2016.

MENDONÇA, A. M. C.; KRITSKI, A. L.; LAND, M. G. P.; SANTANNA, C. C. Abandonment of Treatment for Latent Tuberculosis Infection and Socioeconomic Factors in Children and Adolescents: Rio De Janeiro, Brazil. Plos One, v. 11, p. e0154843, 2016.

MESQUITA, E. D. D.; GIL-SANTANA, L.; RAMALHO, D.; TONOMURA, E.; SILVA, E. C.; OLIVEIRA, M. M.; ANDRADE, B. B.; KRITSKI, A. Associations between systemic inflammation, mycobacterial loads in sputum and radiological improvement after treatment initiation in pulmonary TB patients from Brazil: a prospective cohort study. BMC Infectious Diseases (Online), v. 16, p. 368, 2016.

MICHELETTI, V. C. D.; KRITSKI, A. L.; BRAGA, J. U.; WARNER, D. F. Clinical Features and Treatment Outcomes of Patients with Drug-Resistant and Drug-Sensitive Tuberculosis: A Historical Cohort Study in Porto Alegre, Brazil. Plos One, v. 11, p. e0160109, 2016.

2015

VILLELA, A. D.; EICHLER, P.; PINTO, A. F. M.; RODRIGUES-JUNIOR, V.; YATES III, JR; BIZARRO, C. V.; BASSO, L. A.; SANTOS, D. S. Gene replacement and quantitative Mass spectrometry approaches validate guanosine monophosphate synthetase as essential for Mycobacterium tuberculosis growth. Biochemistry and Biophysics Reports, v. 4, p. 277-282, 2015.

SÁNCHEZ-QUITIAN, Z. A.; RODRIGUES-JUNIOR, V.; REHM, J. G.; EICHLER, P.; TRIVELLA, B.; BARRETTO, D.; BIZARRO, C. V.; BASSO, L. A.; SANTOS, D. S. Functional and structural evidence for the catalytic role played by glutamate-47 residue in the mode of action of Mycobacterium tuberculosis cytidine deaminase. RSC Advances, v. 5, p. 830-840, 2015.

PISSINATE, K.; ROSTIROLLA, D. C.; PINHEIRO, L. M.; SURYADEVARA, P.; YOGEESWARI, P.; SRIRAM, D; BASSO, L. A.; MACHADO, P.; SANTOS, D. S. Synthesis and Evaluation of Thiazolyl-1 -benzo[ ]imidazole Inhibitors of Inosine Monophosphate Dehydrogenase. Journal of the Brazilian Chemical Society, v. 5, p. 1-10, 2015.

ROTTA, M.; PISSINATE, K.; VILLELA, A. D.; BACK, D. F.; TIMMERS, L. F.; BACHEGA, J. F.; DE SOUZA, O. N.; SANTOS, D. S.; BASSO, L. A.; MACHADO, P. Piperazine derivatives: synthesis, inhibition of the Mycobacterium tuberculosis enoyl-acyl carrier protein reductase and SAR studies. European Journal of Medicinal Chemistry, v. 90, p. 436-447, 2015.

PATTA, P. C.; MARTINELLI, L. K. B.; ROTTA, M.; ABBADI, B. L.; SANTOS, D. S.; BASSO, L. A. Mode of Action of Recombinant Hypoxanthine-Guanine Phosphoribosyltransferase from Mycobacterium tuberculosis. RSC Advances, v. 5, p. 74671-74683, 2015.

PETERSEN, G. O.; SAXENA, S.; RENUKA, J.; SONI, V.; YOGEESWARI, P.; SANTOS, D. S.; BIZARRO, C. V.; SRIRAM, D. Structure-based virtual screening as a tool for the identification of novel inhibitors against Mycobacterium tuberculosis 3-dehydroquinate dehydratase. Journal of Molecular Graphics and Modelling, v. 60, p. 124-131, 2015.

LÍRIO, M.; SANTOS, N. P.; PASSOS, L. A. R.; KRITSKI, A.; GALVÃO-CASTRO, B.; GRASSI, M. F. R. Completeness of tuberculosis reporting forms for disease control in individuals with HIV/AIDS in priority cities of Bahia state. Ciência e Saúde Coletiva (Impresso), v. 20, p. 1143-1148, 2015.

SILVA, J. B.; CARDOSO, G. C. P.; RUFFINO-NETTO, A.; KRITSKI, A. L. Os significados da comorbidade para os pacientes vivendo com TB/HIV: repercussões no tratamento. Physis: Revista da saúde coletiva (UERJ, Impresso), v. 25, p. 209-229, 2015.

GOMES, L. L.; VASCONCELLOS, S. E. G.; GOMES, H. M.; ELIAS, A. R.; DA SILVA ROCHA, A.; RIBEIRO, S. C.M.; PANUNTO, A. C.; FERRAZOLI, L.; DA SILVA TELLES, M. A.; IVENS DE, A. M. E.; KRITSKI, A. L.; MOKROUSOV, I.; MANICHEVA, O. A.; LASUNSKAIA, E.; SUFFYS, P. N. Genetic diversity of the Mycobacterium tuberculosis Beijing family in Brazil and Mozambique and relation with infectivity and induction of necrosis in THP-1 cells. Tuberculosis (Edinburgh), v. 95, p. 190-196, 2015.

MENDONÇA, A. M. C.; KRITSKI, A. L.; SANTANNA, C. C. Tuberculosis contact tracing among children and adolescent referred to children's hospital in Rio de Janeiro, Brazil. The Brazilian Journal of Infectious Diseases (Impresso), v. 19, p. 296-301, 2015.

MOREIRA, A. S. R.; HUF, G.; VIEIRA, M. A. M. S.; COSTA, P. A.; AGUIAR, F.; MARSICO, A. G.; FONSECA, L. S.; RICKS, M.; OLIVEIRA, M. M.; DETJEN, A.; FUJIWARA, P. I.; SQUIRE, S. B.; KRITSKI, A. L. Liquid vs Solid Culture Medium to Evaluate Proportion and Time to Change in Management of Suspects of Tuberculosis-A Pragmatic Randomized Trial in Secondary and Tertiary Health Care Units in Brazil. Plos One, v. 10, p. e0127588, 2015.

LANGLEY, I.; SQUIRE, S. B.; DACOMBE, R.; MADAN, J.; E SILVA, J. R. L.; BARREIRA, D.; GALLIEZ, .; OLIVEIRA, M. M.; FUJIWARA, P. I. ; KRITSKI, A. Developments in Impact Assessment of New Diagnostic Algorithms for Tuberculosis Control. Clinical Infectious Diseases, v. 61, p. S126-S134, 2015.

2014

RODRIGUES-JUNIOR, V. S.; DOS SANTOS JUNIOR, A. A.; VILLELA, A. D.; BELARDINELLI, J. M.; MORBIDONI, H. R.; Basso, L. A.; Campos, M. M.; Santos, D. S. IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages. International Journal of Antimicrobial Agents, v. 43, p. 82-85, 2014.

DE MORAES, M. C.; TEMPORINI, C.; CALLERI, E.; BRUNI, G.; DUCATI, R. G.; SANTOS, D. S.; CARDOSO, C. L.; CASS, Q. B.; MASSOLINI, G. Evaluation of capillary chromatographic supports for immobilized human purine nucleoside phosphorylase in frontal affinity chromatographystudies. Journal of Chromatography, v. 1338, p. 77-84, 2014.

ROSTIROLLA, D. C.; DE ASSUNÇÃO, T. M.; BIZARRO, C. V.; BASSO, L. A.; SANTOS, D. S. Biochemical characterization of Mycobacterium tuberculosis IMP dehydrogenase: kinetic mechanism, metal activation and evidence of a cooperative system. RSC Advances: an international journal to further the chemical sciences, v. epub, p. ahead-of print, 2014.

ASSUNÇÃO, T. M. DE; BATISTA, E. L.; DEVES, C.; VILLELA, A. D.; PAGNUSSATTI, V. E.; DIAS, A. C. O.; KRITSKI, A.; JUNIOR, V. R.; BASSO, L. A.; SANTOS, D. S. Real time PCR quantification of viable M. tuberculosis from sputum samples treated with propidium monoazide. Tuberculosis (Edinburgh), v. 94, p. 421-427, 2014.

NIJENBANDRING DE BOER, R.; BAPTISTA DE OLIVEIRA E SOUZA FILHO, J.; COBELENS, F.; DE PAULA RAMALHO, D.; CAMPINO MIRANDA, P. F.; DE LOGO, K.; OLIVEIRA, H.; MESQUITA, E.; OLIVEIRA, M. M.; KRITSKI, A. Delayed culture conversion due to cigarette smoking in active pulmonary tuberculosis patients. Tuberculosis (Edinburgh), v. 94, p. 87-91, 2014.

MICHELETTI, V. C. D.; MOREIRA, J. S.; RIBEIRO, M. O.; KRITSKI, A. L.; BRAGA, J. U. Drug Reistant tuberculosis in subjects included in the Second National Survey on Antituberculosis Drug Resistance in Porto Alegre, Brazil. Jornal Brasileiro de Pneumologia (Impresso), v. 40, p. 155-163, 2014.

TRAJMAN, A.; BASTOS, M. L.; BELO NETO, E.; SILVA, E. M.; DA SILVA LOURENÇO, M. C.; KRITSKI, A.; OLIVEIRA, M. M. Accuracy of Polimerase chain reaction for the diagnosis of pleural tuberculosis. Respiratory Medicine, v. 108, p. 918-923, 2014.

MORAES, M. L.; RAMALHO, D. M. P.; DELOGO, K. N.; MIRANDA, P. F. C.; MESQUITA, E. D. D.; DE MELO GUEDES DE OLIVEIRA, H. M.; NETTO, A. R.; DOS ANJOS, M. J.; KRITSKI, A. L.; DE OLIVEIRA, M. M. Association of Serum Levels of Iron, Copper, and Zinc, and Inflammatory Markers with Bacteriological Sputum Conversion During Tuberculosis Treatment. Biological Trace Element Research, v. 160, p. 176-184, 2014.

MORAES, M. L.; RAMALHO, D. M. P.; DELOGO, K. N.; MESQUITA, E. D. D.; RUFFINO-NETTO, A.; KRITSKI, A.; OLIVEIRA, M. M. Association between serum selenium level and conversion of bacteriological tests during antituberculosis treatment. Jornal Brasileiro de Pneumologia (Impresso), v. 40, p. 269-278, 2014.

FERREIRA JUNIOR, S. L. M.; COSTA, E. R. D.; SANTOS, P. G.; GOMES, H. M. ; SILVA, M. S. N.; ESTEVES, L. S.; OLIVEIRA, M. M.; MASCHMANN, R. A.; KRITSKI, A. L.; SUFFYS, P. N.; ROSSETTI, M. L. R. In house reverse membrane hybridisation assay versus GenoType MTBDRplus and their performance to detect mutations in the genes rpoB, katG and inhA. Memórias do Instituto Oswaldo Cruz (Impresso), v. 109, p. 307-314, 2014.

2013

MACHADO, P.; RITTER, E.; DOS SANTOS, A. J. B.; NEVES, C.; BASSO, L. A.; SANTOS, D. S. Ultrasound-assisted improvement of drug solubility: a simple and useful method for the formation of salts from 4-hydroxy-6-methyl-3-nitropyridin-2(1H)-one. Monatshefte fur Chemie, v. 144, p. 1165-1170, 2013.

ROSADO, L. A.; VASCONCELOS, I. B.; PALMA, M. S.; FRAPPIER, V.; NAJMANOVICH, R. J.; SANTOS, D. S.; BASSO, L. A. The Mode of Action of Recombinant Mycobacterium tuberculosis Shikimate Kinase: Kinetics and Thermodynamics Analyses. Plos One, v. 8, p. e61918, 2013.

JASKULSKI, L.; ROSTIROLLA, D.; ROSADO, L.; TIMMERS, L. F. S. M.; SOUZA, O. N. de; SANTOS, D. S.; BASSO, L. A. Kinetic mechanism and energetics of binding of phosphoryl group acceptors to Mycobacterium tuberculosis Cytidine Monophosphate Kinase. Archives of Biochemistry and Biophysics, v. 536, p. 53-63, 2013.

SANTOS, A. A.; RODRIGUES-JUNIOR, V.; ZANIN, R. F.; BORGES, T. J.; BONORINO, C. ; COUTINHO-SILVA, R.; TAKYIA, C. M.; SANTOS, D. S.; CAMPOS, M. M.; MORRONE, F. B. Implication of purinergic P2X7 receptor in M. tuberculosis infection and host interaction mechanisms: A mouse model study. Immunobiology (Jena. 1979), v. 218, p. 1104-1112, 2013.

KRITSKI, A.; FUJIWARA, P. I.; VIEIRA, M. A.; NETTO, A. R.; OLIVEIRA, M. M.; HUF, G.; BERTEL SQUIRE, S. Assessing new strategies for TB diagnosis in low- and middle-income countries. The Brazilian Journal of Infectious Diseases, v. 13, p. 00052-00054, 2013.

SEIXAS, J. M. FARIA, J. SOUZA FILHO, J. B. O.; VIEIRA, A. F. M.; KRITSKI, A.; TRAJMAN, A. Artificial neural network models to support the diagnosis of pleural tuberculosis in adult patients. The International Journal of Tuberculosis and Lung Disease (Online), v. 17, p. 682-686, 2013.

DOS SANTOS, A. P. G.; PACHECO, A. G.; STAVIACK, A.; GOLUB, J. E.; CHAISSON, R. E.; ROLLA, V. C.; KRITSKI, A. L.; PASSOS, S. R. L.; DE QUEIROZ MELLO, F. C. Safety and effectiveness of HAART in tuberculosis-HIV co-infected patients in Brazil. The International Journal of Tuberculosis and Lung Disease (Online), v. 17, p. 192-197, 2013.

SANTOS, N. P.; LIRIO, M.; PASSOS, L. A. R.; DIAS, J. P.; KRITSKI A.; GALVAO-CASTRO, B. V. M. C. C.; GRASSI, M. F. R. Completeness of tuberculosis reporting forms in five Brazilian capitals with a high incidence of the disease. Jornal Brasileiro de Pneumologia (Impresso), v. 39, p. 221-225, 2013.

RODRIGUES-JUNIOR V. S., DOS SANTOS JUNIOR A. A., VILLELA A. D., BELARDINELLI J. M., MORBIDONI H. R., BASSO L. A., CAMPOS M. M., SANTOS D.S. IQG-607 abrogates the synthesis of mycolic acids and displays intracellular activity against Mycobacterium tuberculosis in infected macrophages. Int J Antimicrob Agents, p. ahead of print, 2013.

VILLELA A. D., DUCATI R. G., ROSADO L. A., BLOCH C. J., PRATES M. V., GONÇALVES D. C., RAMOS C. H., BASSO L. A., SANTOS D. S. Biochemical characterization of uracil phosphoribosyltransferase from Mycobacterium tuberculosis. PLoS One, v. 8, p. e56445, 2013.

LUNARDI J., NUNES J. E., BIZARRO C. V., BASSO L. A., SANTOS D. S., MACHADO P. Targeting the Histidine Pathway in Mycobacterium tuberculosis. Curr Top Med Chem, v. 13, p. 2866-2884, 2013.

WINK P. L., SANCHEZ QUITIAN Z. A., ROSADO L. A., RODRIGUES V. S. Jr., PETERSEN G. O., LORENZINI D. M., LIPINSKI-PAES T., SARAIVA MACEDO TIMMERS L. F., SOUZA O. N., BASSO L. A., SANTOS D.S. Biochemical characterization of recombinant nucleoside hydrolase from Mycobacterium tuberculosis H37Rv. Arch Biochem Biophys, v. 538, p. 80-94, 2013.

PAULI I., DOS SANTOS R. N., ROSTIROLLA D. C., MARTINELLI L. K., DUCATI R. G., TIMMERS L. F., BASSO L. A., SANTOS D. S., GUIDO R. V., ANDRICOPULO A. D., NORBERTO DE SOUZA O. Discovery of new inhibitors of Mycobacterium tuberculosis InhA enzyme using virtual screening and a 3D-pharmacophore-based approach. J Chem Inf Model, v. 53, p. 2390-2401, 2013.

MOREIRA ADA S., HUF G., VIEIRA M. A., FONSECA L., RICKS M., KRITSKI A. L. Performance comparison between the mycobacteria growth indicator tube system and Löwenstein-Jensen medium in the routine detection of Mycobacterium tuberculosis at public health care facilities in Rio de Janeiro, Brazil: preliminary results of a pragmatic clinical trial. J Bras Pneumol, v. 39, p. 365-367, 2013.

2012

LAGO, P.; BOECHAT, N. L.; MIGUEIS, D. P.; ALMEIDA, A. S.; LAZZARINI, L. C. O.; SALDANHA, M. M.; KRITSKI, A. L.; HO, J.; LAPA-E-SILVA, J. R. Interleukin-10 and interferon-gamma patterns during tuberculosis treatment: possible association with recurrence [Short communication]. The International Journal of Tuberculosis and Lung Disease, p. 656-659, 2012.

SANCHEZ, M.; BARTHOLOMAI, P.; ARAKAKI, D.; ENARSON, D.; BISSEL, K.; BARREIRA, D.; HARRIES, A. D.; KRITSKI, A. L. Outcomes of TB Treatment by HIV Status in National Recording Systems in Brazil, 2003 2008. Plos One, v. 7, p. e33129, 2012.

HUF, G.; KRITSKI, A. L. Evaluation of the clinical utility of new diagnostic tests for tuberculosis: the role of pragmatic clinical trials. Jornal Brasileiro de Pneumologia, v. 38, p. 237-245, 2012.

BARBOSA, C. de B.; LAZZARINI, L. C. O.; ELIAS, A. R.; LEUNG, J. A. M.; RIBEIRO, S. B.; SILVA, M. G.; DUARTE, R. S.; SUFFYS, P.; GOMES, H. M.; KRITSKI, A. L.; SILVA, J. R. L. E.; HO, J. L.; BOECHAT, N. L. Tuberculosis caused by RDRio Mycobacterium tuberculosis is not associated with differential clinical features. The International Journal of Tuberculosis and Lung Disease, v. 16, p. 1377-1382, 2012.

AGUIAR, F. S.; ALMEIDA, L. L.; RUFFINO-NETTO, A.; KRITSKI, A. L.; MELLO, F. C. Q.; WERNECK, G. Classification and regression tree (CART) model to predict pulmonary tuberculosis in hospitalized patients. BMC Pulmonary Medicine, v. 12, p. 40, 2012.

GOMES, H. M.; ELIAS, A. R.; OELEMANN, M. A. C.; PEREIRA, M. A. S.; MONTES, F. F. O.; MARSICO, A. G.; KRITSKI, A. L.; FILHO, L. DOS A.; CALDAS, P. C.; POSSUELO, L. G.; CAFRUNE, P.; ROSSETTI, M. L.; LUCENA, N.; SAAD, M. H. F.; CAVALCANTI, H. R.; LEITE, C. Q. F.; DE BRITO, R. C.; LOPES, M. L.; LIMA, K.; SOUZA, M.; TRINDADE, R. DE C.; ZOZIO, T.; SOLA, C.; RASTOGI, N.; SUFFYS, P. N. Spoligotypes of Mycobacterium tuberculosis complex isolates from patients residents of 11 states of Brazil. Infection, Genetics and Evolution, v. 12, p. 649-656, 2012.

ALCANTARA, C. C.; KRITSKI, A. L.; FERREIRA, V. G.; FACANHA, M. C.; PONTES, R. S.; MOTA, R. S.; LEITÃO, T. D. Factors associated with pulmonary tuberculosis among patients seeking medical attention at referral clinics for tuberculosis. Jornal Brasileiro de Pneumologia, v. 38, p. 622-629, 2012.

MATOS, T. P.; KRITSKI, A. L.; NETTO, A. R. Epidemiological aspects of tuberculosis in children and adolescents in Rio de Janeiro. Jornal de Pediatria, v. 88, p. 335-340, 2012.

TIMMERS L. F. S. M.; DUCATI, R. G.; SÁNCHEZ-QUITIAN, Z. A.; BASSO, L. A.; SANTOS, D. S.; DE AZEVEDO JR., W. F. Combining molecular dynamics and docking simulations of the cytidine deaminase from Mycobacterium tuberculosis. Journal of Molecular Modeling, v. 18, p. 467-479, 2012.

CACERES, R. A.; TIMMERS, L. F. S. M.; DUCATI, R. G.; SILVA, D. O.; BASSO, L. A.; DE AZEVEDO JR., W. F.; SANTOS, D. S. Crystal Structure and molecular dynamicis studies of purine nucleoside phosphorylase from Mycobacterium tuberculosis associated with acyclovir. Biochimie, v. 94, p. 155-165, 2012.

BREDA, A.; ROSADO, L. A.; LORENZINI, D.; BASSO, L. A.; SANTOS, D. S. Molecular kinetic and thermodynamic characterization of Mycobacterium tuberculosis orotate phosphorybosiltransferase. Molecular Biosystems, v. 8, p. 572-586, 2012.

DE MORAES, M. C.; DUCATI, R. G.; DONATO, A. J.; BASSO, L. A.; SANTOS, D. S.; CARDOSO, C. L.; CASS, Q. B. Capillary bioreactors based on human Purine Nucleoside Phosphorylase: a new approach for ligands indetification and characterization. Journal of Chromatography, v. 1232, p. 110-115, 2012.

FRANCO, T. M. A.; ROSTIROLA, D.; DUCATI, R. G.; LORENZINI, D.; BASSO, L. A.; SANTOS, D. S. Biochemical characterization of recombinant guaA-encoded guanosine monophosphate synthetase (EC 6.3.5.2) from Mycobacterium tuberculosis H37Rv strain. Archives of Biochemistry and Biophysics, v. 517, p. 1-11, 2012.

SOUZA, E. H.; BASSO, L. A.; SANTOS, D. S.; DIÓGENES, I. C. N.; LONGHINOTTI, E.; LOPES, L. G. F.; MOREIRA, I. S. Isoniazid metal complex reactivity and insights for a novel anti-tubercular drug. Journal of Biological Inorganic Chemistry, v. 17, p. 275-283, 2012.

BREDA, A ; MARTINELLI, L. K.; BIZARRO, C. V.; ROSADO, L.; BRANCHER, C.; SANTOS, D. S.; BASSO, L. A. Wild-type Phosphoribosylpyrophosphate Synthase (PRS) from Mycobacterium tuberculosis: a Bacterial Class II PRS?. Plos One, v. 7, p. 1-13, 2012.

RODRIGUES-JUNIOR, V. S.; DOS SANTOS JUNIOR, A.; DOS SANTOS, A. J.; SCHNEIDER, C. Z.; CALIXTO, J. B.; SOUSA, E. H. S.; DE FRANÇA LOPES, L. G.; SOUTO, A. A.; BASSO, L. A.; SANTOS, D. S.; CAMPOS, M. M. Activity of IQG-607, a new orally active compound, in a murine model of Mycobacterium tuberculosis infection. International Journal of Antimicrobial Agents, v. 40, p. 182-185, 2012.

BREDA, A.; MACHADO, P.; ROSADO, L. A.; SOUTO, A. A.; SANTOS, D. S.; BASSO, L. A. Pyrimidin-2(1H)-ones based inhibitors of Mycobacterium tuberculosis orotate phosphoribosyltransferase. European Journal of Medicinal Chemistry, v. 54, p. 113-122, 2012.

ROSADO, L. A.; CACERES, R.; DE AZEVEDO JR., W. F.; BASSO, L. A.; SANTOS, D. S. Role of Serine140 in the mode of action of Mycobacterium tuberculosis ß-ketoacyl-ACP Reductase (MabA). BMC Research Notes, v. 5, p. 526, 2012.

2011

BERRÊDO-PINHO, M.; KALUME D. E.; CORREA, P. R.; GOMES, L. H.; PEREIRA, M. P.; DA SILVA, R. F.; CASTELLO-BRANCO, L. R. R.; DEGRAVE, W. M.; MENDONÇA-LIMA, L. Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M. bovis BCG Pasteur. BMC Microbiology, v. Apr20, p. 80, 2011.

SIMAS, C. J.; SILVA, D. P.; PONTE, C. G.; CASTELLO-BRANCO, L. R. R.; ANTAS, P. Patterns of in vitro cell-death, metaloproteinase-9 and pro-inflammatory cytokines in human monocytes induced by the BCG vaccine, Moreau strain. Vaccine, v. 29, p. 6446-6450, 2011.

GOMES, L. H.; OTTO, T. D.; VASCONCELOS, E. A.; FERRÃO, P. M.; MAIA, R. M.; MOREIRA, A. S.; FERREIRA, M. A.; CASTELLO-BRANCO, L. R. R.; DEGRAVE, W. M.; MENDONÇA-LIMA, L. Genome sequence of Mycobacterium bovis BCG Moreau, the Brazilian vaccine strain against tuberculosis. Journal of Bacteriology, v. 193, p. 5600-5601, 2011.

TEIXEIRA, E.; KRITSKI, A. L.; RUFFINO-NETTO, A.; STEFFEN, R. ; LAPA-E-SILVA, J. R.; BELO, M.; LUIZ, R. R.; MENZIES, D.; TRAJMAN, A. Medical students at risk of nosocomial tuberculosis. The Journal of Hospital Infection, v. 77, p. 80-81, 2011.

ALBUQUERQUE, P.; CARVALHO, A. C. C.; SOUZA, S. R. G.; MOREIRA, E. C.; GARRIDO, R. Q.; VIEIRA, M. A. M. S.; MATTEELLI, A.; KRITSKI, A. L. Continuous monitoring of implemented tuberculosis control measures in middle-income high-endemic countries. The Journal of Hospital Infection, v. 77, p. 178-179, 2011.

MICHELON, C. T.; ROSSO F.; SCHMID, K. B.; SPERHACKE, R. D.; OLIVEIRA, M. M.; KRITSKI, A. L.; RESENDE JR., L.; DALLA COSTA, E. R.; RIBEIRO, A. W.; VERZA, M.; CAFRUNE, P.; Silva M. S.; KUHLEIS, D.; ZAHA, A.; ROSSETTI, M. L. Colorimetric microwell plate reverse-hybridization assay for Mycobacterium tuberculosis detection. Memórias do Instituto Oswaldo Cruz , v. 106, p. 194-199, 2011.

MIRANDA, S. S.; CARVALHO, W. DA S.; SUFFYS, P. N.; KRITSKI, A. L.; OLIVEIRA, M. M.; ZARATE, N.; ZOZIO, T.; RASTOGI, N.; GICQUEL, B. Spoligotyping of clinical Mycobacterium tuberculosis isolates from the state of Minas Gerais, Brazil. Memórias do Instituto Oswaldo Cruz, v. 106, p. 267-273, 2011.

MALAGHINI, M.; Thomaz-Soccol V.; PROBST, C. M.; KRIEGER, M. A.; PETRI, H.; KRITSKI, A. L.; SOCCOL, C. R. Recombinant antigen production for assays of intradermoreaction for diagnosis and surveillance of tuberculosis. Journal of Biotechnology, v. 156, p. 56-58, 2011.

SQUIRE, S. B.; RAMSAY, A. R. C.; VAN DEN HOF, S.; MILINGTON, K. A.; LANGLEY, I.; BELLO, G.; KRITSKI, A. L.; DETJEN, A.; THOMSON, R.; LIENHARDT, C.; COBELENS, F.; MANN, G. Making innovations accessible to the poor through implementation research. The International Journal of Tuberculosis and Lung Disease, v. 15, p. 862-870, 2011.

KRITSKI, A. L.; RUFFINO-NETTO, A. Publicações na área de tisiologia no Jornal Brasileiro de Pneumologia entre 2004 e 2011: tipos de artigos, modelos de estudo, grau de evidência científica e impacto social. Jornal Brasileiro de Pneumologia, v. 37, p. 285-287, 2011.

TEIXEIRA, R. L.; MORATO, R. G.; CABELLO, P. H.; MUNIZ, L. M.; MOREIRA, ADA, S.; KRITSKI, A. L.; MELLO, F. C.; SUFFYS, P. N.; DE MIRANDA, A. B.; SANTOS, A. R. Genetic polymorphisms of NAT2, CYP2E1 and GST enzymes and the occurrence of antituberculosis drug-induced hepatitis in Brazilian TB patients. Memórias do Instituto Oswaldo Cruz, v. 106, p. 716-724, 2011.

MACHADO, A. C. F. T.; STEFFEN, R.; OXLADE, O.; MENZIES, D.; KRITSKI, A. L.; TRAJMAN, A. Factors associated with delayed diagnosis of pulmonary tuberculosis in the state of Rio de Janeiro, Brazil. Jornal Brasileiro de Pneumologia, v. 37, p. 512-520, 2011.

KRITSKI, A. L.; RUFFINO-NETTO, A. Works in the field of tuberculosis study published in the Brazilian Journal of Pulmonology between 2004 and 2011: types of articles, study models, level of scientific evidence, and social impact. Jornal Brasileiro de Pneumologia, v. 37, p. 285-287, 2011.

CASTRO, C. B. A.; COSTA, P. A.; RUFFINO-NETTO, A.; MACIEL, E. L. N.; KRITSKI, A. L. sAssessment of a clinical score for screening suspected pulmonary tuberculosis cases. Revista de Saúde Pública, v. 45, p. 1110-1116, 2011.

SCHERER, L. C.; SPERHACKE, R. D.; MICHELON, C. T.; JARCZEWSKI, C.; CAFRUNE, P.; RIBEIRO, M.; ROSSETTI, M. L. R.; NETTO, A.; KRITSKI, A. L.; RUPENTHAL, R. Comparison of two laboratory-developed PCR methods for the diagnosis of Pulmonary Tuberculosis in Brazilian patients with and without HIV infection. BMC Pulmonary Medicine, v. 11, p. 15, 2011.

VASO, A.; SANTOS, D. S.; BASSO, L. A.; PALMA, M. S. Hydrogen/Deuterium Exchange Mass Spectrometry for Characterizing Phosphoenolpyruvate-Induced Structural Transitions in Mycobacterium tuberculosis 5-enolpyruvylshikimate-3-phosphate-synthase (EC 2.5.1.1). International Journal of Mass Spectrometry, v. 302, p. 12-18, 2011.

VILLELA, A. D.; SÁNCHEZ-QUITIAN, Z. A.; DUCATI, R. G.; SANTOS, D. S. ; BASSO, L. A. Pyrimidine Salvage Pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry, v. 18, p. 1286-1298, 2011.

DUCATI, R. G.; BREDA, A.; BASSO, L. A.; SANTOS, D. S. Purine Salvage Pathway in Mycobacterium tuberculosis. Current Medicinal Chemistry, v. 18, p. 1258-1275, 2011.

MENDONÇA, J. D.; ADACHI. O.; DUCATI, R. G.; ROSADO, L. A.; SANTOS, D. S.; BASSO, L. A. Kinetic mechanism determination and analysis of metal requirement of dehydroquinate synthase from Mycobacterium tuberculosis H37Rv. Molecular Biosystems, v. 7, p. 119-128, 2011.

ROSTIROLA, D.; BREDA, A.; Rosado, L.A.; PALMA, M. S.; BASSO, L. A.; SANTOS, D. S. UMP kinase from Mycobacterium tuberculosis: mode of action and allosteric interactions, andtheir likely role in pyrimidine metabolism regulation. Archives of Biochemistry and Biophysics, v. 505, p. 202-212, 2011.

SAIDENBERG, D.M.; PASSARELI, A. W.; RODRIGUES, A.V.; BASSO, L.A.; SANTOS, D. S.; PALMA, M.S. Shikimate Kinase (EC2.7.1.71) from Mycobacterium tuberculosis: Kinetics and Structural Dynamics of a Potential Target for Drug Development. Current Medicinal Chemistry, v. 18, p. 1299-1310, 2011.

MARTINELLI, L. K.; DUCATI, R. G.; ROSADO, L. A.; BREDA, A.; SELBACH, B.; SANTOS, D. S.; BASSO, L. A. Recombinant Escherichia coli GMP reductase: catalytic and chemical mechanisms and thermodynamics of enzyme-ligand binary complex formation. Molecular Biosystems, v. 7, p. 1289-1305, 2011.

MEDEIROS, P.S.M.; DUCATI, R. G.; BASSO, L. A.; SANTOS, D. S.; SILVA, L. H. P. Enzyme mechanisms and slow-onset inhibition of Plasmodium falciparum enoyl-acyl carrier protein reductase by an inorganic complex. Enzyme Research, v. 2011, p. 1-11, 2011.

SÁNCHEZ-QUITIAN, Z. A.; TIMMERS L.F.S.M.; CACERES, R. A.; THOMPSON C. E.; BASSO, L. A.; DE AZEVEDO JR, W. F.; SANTOS, D. S. Crystal structure determination and dynamic studies of Mycobacterium tuberculosis cytidine deaminase in complex with products. Archives of Biochemistry and Biophysics, v. 509, p. 108-115, 2011.

NUNES, J. E. S.; DUCATI, R. G.; BREDA, A.; SOUZA, B. M.; PALMA, M. S.; SANTOS, D. S.; BASSO, L. A. Molecular,kinetics, thermodynamics, and structural analyses of Mycobacterium tuberculosis hisD-encoded metal-dependent dimeric histidinol dehydrogenase (EC 1.1.1.23). Archives of Biochemistry and Biophysics, v. 512, p. 143-153, 2011.

2010

SCHREIBER, F.; HUO, Z.; GIEMZA, R.; WOODROW, M.; FENNER, N.; STEPHENS, Z.; DOUGAN, G.; PRIDEAUX, S.; CASTELLO-BRANCO, L. R. R.; LEWIS, D. J. An investigation of clinical and immunological events following repeated aerodigestive tract challenge infections with live Mycobacterium bovis Bacille Calmette Guérin. Vaccine, v. 28, p. 5427-5431, 2010.

CLARK, S.; KELLY, D. L.; BADELL, E.; CASTELLO-BRANCO, L. R. R.; ALDWELL, F.; WINTER, N.; LEWIS, D.; MARSH, P. D. Oral delivery of BCG Moreau Rio de Janeiro gives equivalent protection against tuberculosis but with reduced pathology compared to parenteral BCG Danish vaccination. Vaccine, v. aug 11, p. 20708695, 2010.

MARKEY, K.; HO, M. M.; CHOUDHURY, B.; SEKI, M.; JU, L.; CASTELLO-BRANCO, L. R. R.; GAIROLA, S.; ZHAO, A.; SHIBAYAMA, K.; ANDRE M.; CORBEL, M. J. Report of an international collaborative study to evaluate the suitability of multiplex PCR as an identity assay for different sub-strains of BCG vaccine. Vaccine, v. 20, p. 20732463, 2010.

TEIXEIRA, R. L.; SILVA, F. P.; SILVEIRA, A. R.; CABELLO, P. H.; MENDONCA-LIMA, L.; RABAHI, M. F.; KRITSKI, A. L.; MELLO, F. C.; SUFFYS, P. N.; DE MIRANDA, A. B.; SANTOS, A. R. Sequence analysis of NAT2 gene in Brazilians: Identification of undescribed single nucleotide polymorphisms and molecular modeling of the N-acetyltransferase 2 protein structure. Mutation Research, v. 683, p. 43-49, 2010.

BRITO, R. C.; MELLO, F. C.; ANDRADE, M. K.; OLIVEIRA, H; COSTA, W; MATOS, H. J.; LOURENÇO, M. C.; ROLLA, V. C.; FONSECA, L.; RUFFINO-NETTO, A.; KRITSKI, A. L. Drug-resistant tuberculosis in six hospitals in Rio de Janeiro, Brazil. The International Journal of Tuberculosis and Lung Disease, v. 14, p. 24-33, 2010.

SCHERER, L.; SPERHACKE, R. D.; RUFFINO-NETTO, A.; ROSSETTI, M. L.; VATER, M. C.; KLATSER, P.; KRITSKI, A. L. Cost-effectiveness analysis of PCR for the rapid diagnosis of pulmonary tuberculosis. BMC Infectious Diseases, v. 31, p. 9-216, 2010.

LASSOUNSKAIA, E.; RIBEIRO, S. C.; MANICHEVA, O.; GOMES, L. L.; SUFFYS, P. N.; MOKROUSOV, I.; FERRAZOLI, L.; ANDRADE, M. R.; KRITSKI, A. L.; OTTENHOFF, T.; KIPNIS, T. L.; DA SILVA, W. D.; VISHNEVSKY, B.; OLIVEIRA, M. M.; GOMES, H. M.; BAPTISTA, I. F.; NARVSKAYA, O. Emerging multidrug resistant Mycobacterium tuberculosis strains of the Beijing genotype circulating in Russia express a pattern of biological properties associated with enhanced virulence. Microbes and Infection, v. 12, p. 467-475, 2010.

KRITSKI, A. L. Multidrug-resistant tuberculosis emergence: a renewed challenge. Jornal Brasileiro de Pneumologia, v. 36, p. 157-158, 2010.

MARAIS, B. J.; RAVIGLIONE, M.; DONALD, P. R.; HARRIES, A. D.; KRITSKI, A. L.; GRAHAN, S. M.; EL-SADR, W. M.; HARRINGTON, J.; CHURCHYARD, G.; MWABA, P.; SANNE, I.; KAUFMANN, S. H.; WHITTY, C. J.; ATUN, R.; ZUMLA, A. Scale-up of services and research priorities for diagnosis, management, and control of tuberculosis: a call to action. Lancet, v. 375, p. 2179-2191, 2010.

MATTEELLI, A.; CARVALHO, A. C. C.; DOOLEY, K. E.; KRITSKI, A. L. TMC207: the first compound of a new class of potent anti-tuberculosis drugs. Future Microbiology, v. 5, p. 849-858, 2010.

MANN, G.; SQUIRE, S. B.; BISSEL, K.; ELISEEV, P.; DU TOIT, E.; HESSELING, A.; NICOL, M.; DETJEN, A.; KRITSKI, A. L. Beyond accuracy: creating a comprehensive evidence base for TB diagnostic tools. The International Journal of Tuberculosis and Lung Disease, v. 14, p. 1518-1524, 2010.

SELIG, L.; KRITSKI, A. L.; CASCÃO, A. M.; BRAGA, J. U.; TRAJMAN, A.; CARVALHO, R. M. Proposal for tuberculosis death surveillancein information systems. Revista de Saúde Pública, v. 44, p. 1072-1078, 2010.

SESTER, M.; GIEHL, C.; MCNERNEY, R.; KAMPMANN B.; WALZL G.; CUCHI, P.; WINGFIELD, C.; LANGE, C.; KRITSKI, A. L.; MEYERHANS, A. Challenges and perspectives for improved management of HIV/Mycobacterium tuberculosis co-infection. The European Respiratory Journal, v. 36, p. 1242-1247, 2010.

SELIG, L.; Guedes R.; CASCÃO, A. M.; BRAGA, J. U.; KRITSKI, A. L.; TRAJMAN, A. Tuberculosis and information system: proposal for a death-surveillance strategy. Revista de Saúde Pública, v. 44, p. 1072-1078, 2010.

NETO, B. A. D.; LAPIS, A. A. M.; SPENCER, J.; DIAS, S. L. P.; SANTOS, D. S.; BASSO, L. A.; DUPONT, J. Synthesis and Enzymatic Evaluation of the Guanosine Analogue 2-Amino-6-mercapto-7-methylpurine Ribonucleoside (MESG). Insight into the Phosphorilation Reaction Mechanismo Basef on the Blueprint Transition State: Sn1 or Sn2? Journal of the Brazilian Chemical Society, v. 21, p. 151-156, 2010.

CACERES, R. A.; TIMMERS, L.F.S.M.; PAULI, I.; GAVA, L. M.; DUCATI, R. G.; BASSO, L. A.; SANTOS, D. S.; DE AZEVEDO JR, W. F. Crystal structure and molecular dynamics studies of human purine nucleoside phosphorylase complexed with 7-deazaguanine. Journal of Structural Biology, v. 169, p. 379-388, 2010.

SÁNCHEZ-QUITIAN, Z. A.; SCHNEIDER, C. Z.; DUCATI, R. G.; DE AZEVEDO JUNIOR, W. F.; BASSO, L. A.; SANTOS, D. S. Structural and functional analyses of Mycobacterium tuberculosis Rv3315c-encoded metal-dependent homotetrameric cytidine deaminase. Journal of Structural Biology, v. 169, p. 413-423, 2010.

NETO, B. A. D.; LAPIS, A. A. M.; MANICLHA, F. S.; BATISTA, E.; NETZ, P. A.; ROMINGER, F.; BASSO, L. A.; SANTOS, D. S.; DUPONT, J. On the selective detection of duplex deoxyrybonucleic acids by 2,1,3-benzothiadiazoles fluorophores. Molecular Biosystems, v. 6, p. 967-975, 2010.

BASSO, L. A.; SCHNEIDER, C. Z.; SANTOS, A. J. A. B.; CAMPOS, M. M.; SANTOS, D. S. An inorganic complex that inhibits Mycobacterium tuberculosis Enoyl Reductase as a prototype of a new class of chemotherapeutic agents to treat tuberculosis. Journal of the Brazilian Chemical Society, v. 7, p. 1384-1389, 2010.

VASCONCELOS, I. B.; BASSO, L. A.; SANTOS, D. S. Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberculosis enoyl reductase: implications to function-based antitubercular agent design. Journal of the Brazilian Chemical Society, v. 21, p. 1503-1508, 2010.

DUCATI, R. G.; BASSO, L. A.; SANTOS, D. S.; DE AZEVEDO JR., W. F. Crystallographic and docking studies of purine nucleoside phosphorilase from Mycobacterium tuberculosis. Bioorganic & Medicinal Chemistry, v. 18, p. 4769-4774, 2010.

DUCATI, R. G.; SOUTO A. A.; CACERES, R. A.; DE AZEVEDO JR, W. F. de ; BASSO, L. A.; SANTOS, D. Purine Nucleoside Phosphorylase as a molecular target to develop active compounds against Mycobacterium tuberculosis. International Review of Biophysical Chemistry, v. 01, p. 34-40, 2010.

2009

BADELL, E.; NICOLLE, F.; CLARK, S.; MAJLESSI, L.; BOUDOU, F.; MARTINO, A.; CASTELLO-BRANCO, L. R. R.; LECLERC, C.; LEWIS, D. J.; MARSH, P. D.; GICQUEL, B.; WINTER, N. Protection against tuberculosis induced by oral prime with Mycobacterium bovis BCG and intranasal subunit boost based on the vaccine candidate Ag85B-ESAT-6 does not correlate with circulating IFN-gamma producing T-cells. Vaccine, v. 27, p. 28-37, 2009.

AGUIAR, F. S.; VIEIRA, M. A. M. S.; MARKST, A.; BUARQUE, C. N.; MARSICO, A. G.; FONSECA, L. S.; CHAISSON, R.; KRITSKI, A. L.; WERNECK, G.; MELLO, F. Prevalence of tuberculosis drug resistance in HIV/AIDS reference hospital in Rio de Janeiro, Brazil. The International Journal of Tuberculosis and Lung Disease, v. 13, p. 54-61, 2009.

MALAGHINI, M.; BROCKELT, S. R.; BURGER, M.; KRITSKI, A. L.; THOMAZ-SOCCOL, V. Molecular characterization of Mycobacterium tuberculosis isolated in the State of Parana in southern Brazil. Tuberculosis, v. 89, p. 101-105, 2009.

MIRANDA, S. S.; TOLEDO, A. R. P.; RIBEIRO, S R.; CAMPOS, I. M.; STHUR, P. M. O. D.; KRITSKI, A. L. Incidence of TB diagnosed in the emergency room of a teaching hospital in southeastem Brazil. Jornal Brasileiro de Pneumologia, v. 35, p. 174-178, 2009.

CONDE, M. B.; EFRON, A.; LOREDO, C.; DE SOUZA, G. R.; GRACA, N. P.; CEZAR, M. C.; RAM, M.; CHAUDHARY, M. A.; BISHAI, W. R.; KRITSKI, A. L.; CHAISSON, R. Moxifloxacin versus ethambutol in the initial treatment of tuberculosis: a double-blind, randomised, controlled phase II trial. Lancet, v. 373, p. 1183-1189, 2009.

DA COSTA, P. A.; TRAJMAN, A.; MELLO, F. C. Q.; SOUZA, S. R. G.; SILVA, M. A.; GARRET, D.; RUFFINO-NETTO, A.; KRITSKI, A. L. Administrative measures for preventing Mycobacterium tuberculosis infection among healthcare workers in a teaching hospital in Rio de Janeiro, Brazil. The Journal of Hospital Infection, v. 72, p. 57-64, 2009.

DALLA COSTA, E. R.; OSORIO, M.; SILVA, M. S.; ARNOLD, L. S.; ROSTIROLLA, D. C.; CAFRUNE, P.; ESPINOZA, R. C.; PALACI, M.; TELLES, M. A.; RITACCO, V.; SUFFYS, P.; LOPES, M. L.; CAMPELO, C. L.; MIRANDA, S. S.; KREMER, K.; DA SILVA, P. E.; FONSECA, L. S.; HO, J.; KRITSKI, A. L.; ROSSETTI, M. L. Correlations of mutations in katG, oxyR-ahpC and inhA genes and in vitro susceptibility in Mycobacterium tuberculosis clinical strains segregated by spoligotype families from tuberculosis prevalent countries in South America. BMC Microbiology, v. 9, p. 39, 2009.

SCATENA, L. M.; VILLA, T. S.; RUFFINO-NETTO, A.; KRITSKI, A. L.; FIGUEIREDO, T. M.; VENDRAMINI, S.; ASSIS, M. M.; MOTTA, M. C. S. Difficulties in the accessibility to health services for tuberculosis diagnoses in Brazilian municipalities. Revista de Saúde Pública, v. 43, p. 389-397, 2009.

ALMEIDA, A. S.; LAGO, P.; BOECHAT, N. L.; HUARD, R. C.; LAZZARINI, L. C. O.; SANTOS, A. R.; NOCIARI, M.; ZHU, H.; PEREZ-SWEENEY, B. M.; BANG, H.; NI, Q.; HUANG, J.; GIBSON, A. L.; FLORES, V. C.; REGO, L.; KRITSKI, A. L.; LAPA-E-SILVA, J. R.; HO, J. L. Tuberculosis is associated with a down-modulatory lung immune response that impairs Th1-type immunity. The Journal of Immunology, v. 183, p. 718-731, 2009.

SELIG, L.; GUEDES, R.; KRITSKI, A. L.; SPECTOR, N.; LAPA-E-SILVA, J. R.; BRAGA, J. U.; TRAJMAN, A. Uses of tuberculosis moratality surveillance to identify programme errors and improve database reporting. The International Journal of Tuberculosis and Lung Disease, v. 13, p. 982-988, 2009.

MOTTA, M. C. S.; VILLA, T. S.; GOLUB, J.; KRITSKI, A. L.; RUFFINO-NETTO, A.; SILVA, D. F.; HARTER, R. G.; SCATENA, L. M. Access to tuberculosis diagnosis in Itaboraí City, Rio de Janeiro, Brazil: the patient's point of view. The International Journal of Tuberculosis and Lung Disease, v. 13, p. 1137-1141, 2009.

DE OLIVEIRA, H. M.; BRITO, R. C.; KRITSKI, A. L.; RUFFINO-NETTO, A. Epidemiological profile of hospitalized patients with TB at a referral hospital in the city of Rio de Janeiro, Brazil. Jornal Brasileiro de Pneumologia, v. 35, p. 780-787, 2009.

SCHERER, L.; SPERHACKE, R. D.; RUFFINO-NETTO, A.; ROSSETTI, M. L.; VATER, M. C.; KLATSER, P.; KRITSKI, A. L. Cost-effectiveness analysis of PCR for the rapid diagnosis of pulmonary tuberculosis. BMC Infectious Diseases, v. 9, p. 216-216, 2009.

THUM, C.; SCHNEIDER, C. Z.; PALMA, M. S.; SANTOS, D. S.; BASSO, L. A. The Rv1712 Locus from Mycobacterium tuberculosis H37Rv Codes for a Functional CMP Kinase That Preferentially Phosphorylates dCMP. Journal of Bacteriology, v. 191, p. 2884-2887, 2009.

BIAZUS, G.; SCHNEIDER, C. Z.; PALMA, M. S.; BASSO, L. A.; SANTOS, D. S. Hypoxanthine-guanine Phosphoribosyltransferase from Mycobacterium tuberculosis H37Rv: cloning,expression, and biochemical characterization. Protein Expression and Purification, v. 66, p. 185-190, 2009.

DUCATI, R. G.; SANTOS, D. S.; BASSO, L. A. Substrate Specificity and Kinetic Mechanism of Purine Nucleoside Phosphorylase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics, v. 486, p. 155-164, 2009.

RODRIGUES JUNIOR, V. S.; BASSO, L. A.; SANTOS, D. S. Homogeneous recombinant Mycobacterium tuberculosis shikimate dehydrogenase production: an essential step twards target-based drug design. International Journal of Biological Macromolecules, v. 45, p. 200-205, 2009.

WERLANG, I. C.; SCHNEIDER, C.; BASSO, L. A.; SANTOS, D. S. Identification of Rv3852 as a nucleoid-associated protein in Mycobacterium tuberculosis. Microbiology, v. 155, p. 2652-2663, 2009.

CZEKSTER, C. M.; Neto, B. A. D.; LAPIS, Alexandre A.M.; DUPONT, J.; SANTOS, D. S.; BASSO, L. A. Steady-state kinetics of indole-3-glycerol phosphate synthase from Mycobacterium tuberculosis. Archives of Biochemistry and Biophysics, p. 19-26, 2009.

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